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Hiromitsu Takeyama Selected Research

Interleukin-1alpha (Interleukin 1 alpha)

5/2009Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications.
8/2008Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines.
2/2006Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression.
10/2005Interleukin-1alpha enhances IL-8 secretion through p38 mitogen-activated protein kinase and reactive oxygen species signaling in human pancreatic cancer cells.
1/2003Enhancement of integrins by interleukin-1alpha, and their relationship with metastatic and invasive behavior of human pancreatic ductal adenocarcinoma cells.
1/2003Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer.

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Hiromitsu Takeyama Research Topics

Disease

40Neoplasms (Cancer)
12/2016 - 01/2003
24Pancreatic Neoplasms (Pancreatic Cancer)
12/2016 - 01/2003
22Infections
12/2014 - 10/2002
19Neoplasm Metastasis (Metastasis)
12/2016 - 01/2002
10Colorectal Neoplasms (Colorectal Cancer)
04/2017 - 07/2007
8Stomach Neoplasms (Stomach Cancer)
09/2016 - 07/2007
6Esophageal Neoplasms (Esophageal Cancer)
09/2016 - 01/2002
4Esophageal Squamous Cell Carcinoma
06/2016 - 03/2011
3Carcinogenesis
05/2014 - 02/2009
3Colonic Neoplasms (Colon Cancer)
10/2011 - 03/2005
3Adenocarcinoma
09/2006 - 01/2003
3Carcinoma (Carcinomatosis)
11/2005 - 01/2002
2Pain (Aches)
10/2016 - 05/2006
2Lymphatic Metastasis
09/2016 - 06/2010
2Rupture
12/2015 - 01/2002
2Fistula
01/2015 - 01/2002
2Ischemia
09/2014 - 06/2010
2Inguinal Hernia (Direct Inguinal Hernia)
03/2014 - 04/2010
2Wounds and Injuries (Trauma)
07/2012 - 02/2012
2Rectal Neoplasms (Rectal Cancer)
06/2008 - 03/2005
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
02/2007 - 10/2006
1Neuralgia (Stump Neuralgia)
10/2016
1Obesity
01/2016
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2016

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
09/2016 - 01/2003
15Anti-Infective Agents (Microbicides)IBA
12/2014 - 10/2002
12IntegrinsIBA
01/2008 - 01/2003
9InterleukinsIBA
01/2012 - 01/2003
8EnzymesIBA
01/2016 - 01/2003
7ImmunosorbentsIBA
01/2014 - 01/2003
6Interleukin-1alpha (Interleukin 1 alpha)IBA
05/2009 - 01/2003
5Biological ProductsIBA
04/2014 - 03/2005
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2014 - 08/2008
5LigandsIBA
03/2013 - 01/2003
5Messenger RNA (mRNA)IBA
03/2011 - 10/2006
4Pharmaceutical PreparationsIBA
07/2014 - 11/2004
4NF-kappa B (NF-kB)IBA
07/2010 - 07/2007
4Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
07/2007 - 08/2003
4Integrin alpha6IBA
06/2007 - 11/2005
4Proliferating Cell Nuclear Antigen (PCNA)IBA
06/2007 - 11/2005
3Interleukin-6 (Interleukin 6)IBA
04/2017 - 12/2015
3CytokinesIBA
12/2015 - 01/2012
3zerumboneIBA
04/2014 - 01/2014
3Carcinoembryonic AntigenIBA
11/2013 - 08/2010
3Interleukin-8 (Interleukin 8)IBA
01/2012 - 10/2005
3Small Interfering RNA (siRNA)IBA
05/2010 - 10/2005
3Laminin (Merosin)IBA
01/2008 - 01/2003
3Interleukin-1 Type I ReceptorsIBA
06/2007 - 11/2005
2Bevacizumab (Avastin)FDA Link
04/2017 - 01/2016
2Peptides (Polypeptides)IBA
12/2016 - 01/2012
2GemcitabineFDA Link
12/2016 - 07/2006
2Reactive Oxygen Species (Oxygen Radicals)IBA
12/2015 - 10/2005
2Indicators and Reagents (Reagents)IBA
10/2015 - 03/2006
2Cisplatin (Platino)FDA LinkGeneric
10/2013 - 01/2002
2AntibodiesIBA
03/2013 - 02/2006
2Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2012 - 10/2010
2ChemokinesIBA
01/2012 - 02/2009
2Chemokine CXCL12IBA
01/2012 - 02/2009
2Conditioned Culture MediaIBA
07/2010 - 10/2005
2Insulin-Like Growth Factor I (IGF-1)IBA
06/2010 - 05/2010
2Phosphatidylinositols (Phosphatidylinositol)IBA
11/2009 - 04/2009
2Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
08/2008 - 01/2003
2Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
10/2007 - 07/2007
2Gabexate (Foy)IBA
10/2007 - 07/2007
2Stem Cell FactorIBA
09/2007 - 10/2006
2Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA
09/2007 - 10/2006
2alpha-Fetoproteins (alpha-Fetoprotein)IBA
07/2007 - 01/2002
2FosfomycinFDA Link
06/2007 - 12/2006
2CarbohydratesIBA
09/2006 - 03/2005
2AntigensIBA
09/2006 - 03/2005
2Integrin beta1IBA
02/2006 - 10/2005
2Adenosine Monophosphate (AMP)IBA
02/2003 - 10/2002
2Fluorouracil (Carac)FDA LinkGeneric
11/2002 - 01/2002
1Methadone (Dolophine)FDA LinkGeneric
10/2016
1Opioid Analgesics (Opioids)IBA
10/2016
1Analgesics (Analgesic Drugs)IBA
10/2016
1Cadherins (E-Cadherin)IBA
09/2016
1Connexin 43 (Connexin43)IBA
06/2016
1ConnexinsIBA
06/2016
1Transcription Factors (Transcription Factor)IBA
01/2016
1AmylasesFDA Link
01/2016
1Itraconazole (Sporanox)FDA LinkGeneric
01/2016
1Transcription Factor 4IBA
01/2016

Therapy/Procedure

12Therapeutics
01/2016 - 01/2002
9Drug Therapy (Chemotherapy)
04/2017 - 01/2002
4Gastrectomy
06/2015 - 07/2007
3Stents
01/2015 - 04/2009
3Surgical Instruments (Clip)
08/2013 - 06/2011
3Colectomy
02/2012 - 01/2006
2Pancreaticoduodenectomy
01/2016 - 04/2004
2Cystectomy
12/2015 - 02/2011
2Lymph Node Excision (Lymph Node Dissection)
06/2015 - 12/2014
2Hepatectomy
05/2014 - 11/2013
2Herniorrhaphy
03/2014 - 07/2012
2Laparotomy
10/2011 - 07/2007
2Conservative Treatment
02/2011 - 05/2006
2Esophagectomy
06/2010 - 01/2002
2Colonic Pouches (S Pouch)
01/2006 - 07/2005
2Radiotherapy
03/2005 - 01/2002
1Palliative Care (Palliative Therapy)
10/2016